Local Stability Compensation

<b>bpRNA_data</b> contains tab-delimited files for bulges, hairpin loops, and internal loops in bpRNA-1 and contains a list of the structures that are a part of bpRNA-1m90, which may be used to filter the structures down to a subset with &lt; 90% sequence identity. The tab-delimited text files contain information (including calculated thermodynamic values) about each instance of a bulge, hairpin, and internal loop in bpRNA-1m as well as information about the stems adjacent to the each loop. Within the directory 'refold' is a similar set of .txt files containing information on bulges, hairpins, and internal loops after folding CRW and RFAM structures using existing pairs as a constraint.<b>library_data</b> contains DMS reactivity data in the form of the original filtered sequence libraries used in the study in .csv format, as well as structure type energy (.ste) files for both the library sequences as designed and the library sequences as folded according to ViennaRNA's RNAfold. Lastly, the .txt files contain processed tab-delimited data collected for each sequence in each library, including free energies, average reactivities, and area under the receiver operator curve (AUROC) values for different localities.

<b>bpRNA_data</b> 收录了bpRNA-1中凸起环、发夹环与内部环对应的制表符分隔文件，同时包含bpRNA-1m90所涵盖的结构列表，可用于将结构筛选至序列同一性低于90%的子集。该制表符分隔文本文件收录了bpRNA-1m中每一处凸起环、发夹环与内部环的相关信息（包括计算得到的热力学数值），以及各环相邻茎区的相关信息。在'refold'目录下，存有另一组类似的.txt文件，记录了以现有碱基配对作为约束条件，对CRW与RFAM结构进行折叠后得到的凸起环、发夹环与内部环的相关信息。
<b>library_data</b> 包含本研究使用的原始过滤序列文库的DMS反应性数据（DMS reactivity data），格式为逗号分隔值(.csv)文件；同时收录了针对文库设计序列以及经ViennaRNA的RNAfold折叠得到的文库序列的结构类型能量(.ste)文件。此外，.txt文件包含针对每个文库中各序列收集的经处理的制表符分隔数据，包括自由能、平均反应性，以及针对不同局部区域的接收者操作特征曲线下面积（Area Under the Receiver Operating Characteristic Curve, AUROC）数值。