Excitatory and inhibitory D-serine binding to the NMDA receptor (10dser-10glu)

No glycans, 10 D-serine and 10 glutamate ligands<br>We studied the binding of D-serine to the GluN1/GluN2A NMDA receptor ligand-binding domain and found that D-serine binds to both GluN1 and GluN2A subunits, acting as an agonist for GluN1 and a competitive inhibitor at high concentrations for GluN2A.

无聚糖，共包含10个D-丝氨酸配体与10个谷氨酸配体。本研究针对D-丝氨酸与GluN1/GluN2A型N-甲基-D-天冬氨酸（NMDA）受体配体结合域的结合过程展开探究，结果发现D-丝氨酸可结合至GluN1与GluN2A两个亚基，对GluN1亚基发挥激动剂作用，而在高浓度下则对GluN2A亚基起到竞争性抑制剂的效果。