Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium and age-associated mitochondrial dysfunction.

We have performed single cell RNA-sequencing to characterize the murine esophageal epithelium in young and aged mice. Overall design: We used peeled esophageal epithelium from young (=4 months) and aged (=18 months) mice to investigate the molecular heterogeneity of the esophageal epithelium at single cell resolution.

本研究通过单细胞RNA测序（single cell RNA-sequencing）技术，对年轻与老年小鼠的食管上皮组织开展特征解析。总体设计：本研究采集4月龄年轻小鼠及18月龄老年小鼠的剥离食管上皮组织，以单细胞分辨率探究食管上皮组织的分子异质性。