Neurological Recovery and Infarction Volume.

The surviving animals (MSC 1-hour group, n = 32; control group, n = 27) were subjected to behavioral tests by using the rotarod test and by measuring the modified Neurologic Severity Score (NSS) at baseline and at 1, 4, 7, 10, and 14 days after MCAO. In the rotarod test, the MSC 1-hour group exhibited statistically significant functional recovery at 10 and 14 days (A). The modified NSS at 14 days also revealed greater recovery in the MCS 1-hour group than in the control group. Because the modified NSS scores at 14 days of all 4 rats in control group were 7, the error bar could not be drawn (B). The infarction volume was smaller in the MSC 1-hour group than in the control group at 10 and 14 days after MCAO (C).

存活的实验动物（间充质干细胞（Mesenchymal Stem Cell, MSC）1小时组，n=32；对照组，n=27）于基线状态及大脑中动脉闭塞（Middle Cerebral Artery Occlusion, MCAO）造模后1、4、7、10、14天，通过转棒疲劳实验（rotarod test）与改良神经功能缺损评分（modified Neurologic Severity Score, NSS）完成行为学检测。在转棒疲劳实验中，MSC 1小时组在造模后10天及14天表现出具有统计学意义的功能恢复（图A）。造模后14天的改良NSS评分结果同样显示，MSC 1小时组的神经功能恢复程度优于对照组。由于对照组全部4只大鼠在造模后14天的改良NSS评分均为7分，故无法绘制误差棒（图B）。在MCAO造模后10天及14天，MSC 1小时组的脑梗死体积较对照组更小（图C）。