Expression data from lung tissues of IPF patients and Normal Control. Homo sapiens

Idiopathic pulmonary fibrosis (IPF) is a progressive lethal interstitial lung disease of unkown etiology with limited effective therapies. The pathogenic mechanisms of IPF remain unkown. Emerging evidences indicate that abnormal behaviors of fibroblasts in IPF are associated with a variety of genetic alterations and aberrant reactivation of developmental signaling pathways. We compared gene expression profiles in fibrotic lung tissues from IPF patients and normal lung tissues from patients with primary spontaneous pneumothorax using cDNA microarray to examine the mechnisms involved in the pathogenesis of IPF. Overall design: Lung tissues were obtained from 5 IPF patients and 3 normal control subjects (patients with primary spontaneous pneumothorax). Gene expression profiling was performed using GeneChip Human Transcriptome Array 2.0.

特发性肺纤维化（Idiopathic Pulmonary Fibrosis, IPF）是一种病因未明的进展性致死性间质性肺疾病，目前有效治疗手段十分有限。其发病机制至今尚未阐明。越来越多的研究证据表明，IPF患者体内成纤维细胞的异常行为与多种遗传改变及发育信号通路的异常激活密切相关。本研究采用cDNA微阵列（cDNA microarray）技术，对IPF患者的纤维化肺组织与原发性自发性气胸患者的正常肺组织的基因表达谱进行比较分析，以探究IPF发病相关的分子机制。研究设计概况：本研究共纳入5例IPF患者的纤维化肺组织样本，以及3例原发性自发性气胸患者的正常肺组织作为对照；采用GeneChip人类转录组阵列2.0（GeneChip Human Transcriptome Array 2.0）完成基因表达谱检测。