16s rRNA amplicon sequencing of skin samples collected from foot

Tinea pedis is a chronic, recurrent superficial fungal infection that most commonly involves the toe web spaces. We here applied high-throughput sequencing technique to comprehensively investigate the bacterial and fungal microbiomes in patients with tinea pedis, subjects in the remission stage and healthy subjects. According to our data, superficial fungal infection was significantly correlated with alterations in the bacterial communities with increased Shannon diversity. The fungal taxonomy analysis demonstrated that the dominant genera might be inconsistent with the culture results. A high abundance of Streptococcus spp. was revealed in the patients, and a strong positive correlation was found between this pathogen and Trichophyton. Further studies are needed to investigate the crosstalk between the bacterial and fungal communities in the pathogenesis of recurrent fungal infection.In this dataset, we showed the 16s rRNA V4 amplicon sequencing of skin samples collected from toe web spaces of patients with tinea pedis (Pt), patients at remission stage (rem) and healthy controls (h.c.).

足癣（Tinea pedis）是一种慢性、易复发的浅表真菌感染性疾病，最常累及趾间间隙。本研究采用高通量测序技术（high-throughput sequencing），对足癣患者、疾病缓解期受试者及健康受试者的皮肤细菌与真菌微生物组进行了全面解析。基于本研究数据，浅表真菌感染与细菌群落的显著改变密切相关，该改变伴随香农多样性指数（Shannon diversity）升高。真菌分类学分析显示，优势菌属与传统培养结果可能存在不一致。患者样本中检测到高丰度的链球菌属（Streptococcus spp.），且该病原菌与毛癣菌属（Trichophyton）呈显著正相关。后续仍需开展深入研究，以阐明复发性真菌感染发病过程中细菌与真菌群落间的互作机制。本数据集收录了从足癣患者（Pt）、缓解期患者（rem）及健康对照（h.c.）的趾间间隙采集的皮肤样本的16S rRNA V4区扩增子测序（16s rRNA V4 amplicon sequencing）数据。