Transcriptome changes in the liver of Pelteobagrus fulvidraco fed with histamine-rich diets. Tachysurus fulvidraco

Histamine was produced by bacterial species known to possess histidine decarboxylase during the fish meal production and storage. High levels of histamine in feedstuffs are considered to be toxic. A transcriptome was conducted to investigate which gene expression would be affected by exogenous histamine. The present study demonstrated that histamine-rich diet affected many genes of the liver in Pelteobagrus fulvidraco, including the genes related with immunology, inflammation and mentalism.

在鱼粉的生产与储存过程中，携带组氨酸脱羧酶(histidine decarboxylase)的细菌可合成组胺(Histamine)。饲料原料中组胺含量过高时，被认为具有毒性。本研究通过转录组(Transcriptome)分析，探究外源组胺对基因表达的影响。研究结果表明，富含组胺的日粮会影响黄颡鱼(Pelteobagrus fulvidraco)肝脏内的大量基因表达，其中包括与免疫学、炎症反应及代谢相关的基因。