Effects of dutasteride and tamsulosin on penile morphology in a rodent model

ABSTRACT Purpose To evaluate the penile morphology after the isolated and combined administration of dutasteride and tamsulosin in a rodent model. Materials and Methods Forty male rats were assigned into the following groups: Control group (C, receiving distilled water, n=10); Dutasteride group (D, receiving 0.5 mg/Kg/day of dutasteride, n=10); Tamsulosin group (T, receiving 0.4 mg/Kg/day of tamsulosin, n=10); and Dutasteride associated with Tamsulosin group (DT, receiving both drugs n = 10). All drugs were administered via oral gavage. After 40 days, the animals were submitted to euthanasia and their penises were collected for histomorphometric analyses. Data were compared using one-way ANOVA followed by Bonferroni’s post-test, considering p

摘要 研究目的：评估在啮齿动物模型中单独及联合应用度他雄胺（dutasteride）与坦索罗辛（tamsulosin）后的阴茎形态学变化。材料与方法：将40只雄性大鼠分为以下4组：对照组（C，给予蒸馏水，n=10）、度他雄胺组（D，每日给予0.5 mg/kg度他雄胺，n=10）、坦索罗辛组（T，每日给予0.4 mg/kg坦索罗辛，n=10）以及度他雄胺联合坦索罗辛组（DT，同时给予两种药物，n=10）。所有药物均经口灌胃给药。造模40天后，对所有动物实施安乐死，采集阴茎组织用于组织形态计量学分析。数据采用单因素方差分析（one-way ANOVA）及Bonferroni事后检验进行比较，以p