Viral Status Predicts Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma [RNA-Seq]. Viral Status Predicts Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma [RNA-Seq]

To understand the global methylation pattern in MCC Overall design: MCC cell lines' global methylation patterns are profiled by Infinium Methylation EPIC Array. MCC cell lines are also treated with 5-aza-2’-deoxyazacitidine and/or trichostatin A and profiled for gene expression with RNA-seq.

为探究默克尔细胞癌（Merkel Cell Carcinoma, MCC）的全基因组甲基化模式，本数据集的实验整体设计如下：采用Infinium甲基化EPIC阵列（Infinium Methylation EPIC Array）对MCC细胞系的全基因组甲基化模式进行检测分析；此外，对MCC细胞系施加5-氮杂-2'-脱氧胞苷（5-aza-2’-deoxyazacitidine）和/或曲古抑菌素A（trichostatin A）处理后，通过RNA测序（RNA-seq）完成基因表达谱的检测分析。