Further insights on the curious case of bishop Peder Winstrup’s burial.. Related in death? Further insights on the curious case of bishop Peder Winstrup and his grandchild’s burial.

In 2021 we published results of genomic analyses carried out on the famous bishop of Lund, Peder Winstrup, and the mummified remains of a 5–6-month-old foetus discovered in the same burial [1]. We concluded that the two individuals were second-degree relatives and explored the genealogy of Peder Winstrup to further understand the possible relation between them. Through this analysis we found that the boy was most probably Winstrup’s grandson, and that the two were equally likely related either through Winstrup’s son, Peder, or his daughter Anna Maria von Böhnen. To further resolve the specific kinship relation, we have generated more genomic data from both Winstrup and the boy, and implemented more recently published analytical tools in detailed Y chromosome and X chromosome-based kinship analyzes to distinguish between the competing hypotheses regarding maternal and paternal relatedness. We find that individuals’ Y chromosome lineages belong to different sub-lineages and that the X chromosomal kinship coef-ficient calculated between the two individuals are elevated, suggesting a grandparent-grandchild relation through a female, i.e., Anna Maria von Böhnen. Finally, we also performed metagenomic analyses which did not identify any pathogens that could be unambiguously associated with the fatalities

2021年，我们针对著名隆德主教佩德尔·温斯特鲁普（Peder Winstrup）以及同一墓葬中出土的5~6月龄男胎的木乃伊遗骸开展基因组分析，并发表了相关研究成果[1]。此前我们判定二者为二级亲属，并通过梳理佩德尔·温斯特鲁普的家族谱系，进一步探究二者间可能的亲属关联。经该分析，我们推断这名男胎大概率是温斯特鲁普的外孙，且二者通过温斯特鲁普之子佩德尔，或是其女儿安娜·玛丽亚·冯·博恩（Anna Maria von Böhnen）建立亲属关系的概率不相上下。为进一步明确二者的具体亲属关系，我们新增了温斯特鲁普与这名男胎的更多基因组测序数据，并采用近年发表的分析工具，针对Y染色体与X染色体开展精细化的亲缘关系分析，以甄别关于母系与父系亲缘关联的各类竞争性假说。我们发现二者的Y染色体谱系分属不同的亚谱系，且二者间计算得到的X染色体亲缘系数（X chromosomal kinship coefficient）显著升高，这表明二者通过女性亲属（即安娜·玛丽亚·冯·博恩）建立了外祖孙亲缘关系。此外，我们还开展了宏基因组分析（metagenomic analyses），未发现可明确与该二人生前致死病因相关的病原体。