GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization

GEF-H1 controls transcriptional programs that mediate antitumor immuity upon microtubule destabilization. Overall design: Transcriptional responses in BMDCs from WT and Arhgef2 deficient after 5 hours of microtubule destbilization.

GEF-H1（鸟苷酸交换因子H1，Guanine nucleotide exchange factor H1）可调控介导微管解稳定后抗肿瘤免疫的转录程序。整体实验设计：对野生型（Wild Type, WT）和Arhgef2基因缺陷型小鼠的骨髓源树突状细胞（Bone Marrow-derived Dendritic Cells, BMDCs）在经微管解稳定处理5小时后的转录应答进行检测。