Dataset on cadaveric human abdominal aorta aneurysm biomechanics (uniaxial) and histology

The present dataset is a collection of information about the biomechanical behavior and histological characterization of abdominal aortic aneurysms (AAA) harvested during the autopsy procedure. The primary hypothesis of the present research is: Do cadaveric AAA walls, when previously stressed by inflation, conserve significant resistance against tearing comparable to no previously stressed aortas described in the literature? Eight AAAs (6 fusiform and two saccular) were carefully dissected and had their branches ligated with cotton or prolene sutures. Each specimen has been submitted to intraluminal pressurization, up to the rupture of their wall. This pressurization was made through the inflation of an air balloon inside the specimens up to their rupture. Four samples were collected from each specimen (two from each side of the rupture border and two control samples, one from a proximal and a second from a distal no dilated region of the vessel) for uniaxial tensile tests and histological analysis. The uniaxial tensile test utilized the INSTRON SPEC 2200 device and was coordinated by INSPEC software and SERIES IX software. The variables measured through this test were failure stress, failure tension, and failure strain. Each sample test generated a chart representing the relationship between stress and strain. The histological analysis included Picrosirius (collagen fibers) and Voerhoeff (elastic fibers) stains. Unfortunately, some samples were lost, especially during histological processing. A quantitative analysis (collagen and elastic fibers) was made using the software Pannoramic Viewer/Case Viewer.1 Notable findings: Even after being stretched/stressed up to their rupture, the specimens conserved uniaxial biomechanical properties comparable to AAA and normal aorta samples previously described in the literature by Monteiro e Nynomiya respectively.2,3 DATA DESCRIPTION: a) Biomechanical Data: For each valid sample test, three documents are generated: 1. Stress X strain chart 2. Table (excel file containing all the values related to the stress X strain chart 3. A report from the Biomechanical test software containing details of the test All charts contain a notification in their left upper corner about the failure stress, strain and tension of each sample. It is important to highlight here that some samples did not produce valid biomechanical tests, so they do not have their results included here. b) Histological Data: The percentage of coverage of collagen fibers and elastin fibers is expressed in table I in decimal numbers (for example, 0.36 = 36%). Similarly to the sampling for biomechanical tests, four samples were harvested from each aorta, when it was feasible. Each case has a "histology files" folder containing the images (.JPG) used for the analysis. Ps.: Case C samples (histology) were damaged during processing (therefore they were not included in the present dataset).

本数据集为尸检获取的腹主动脉瘤（abdominal aortic aneurysms, AAA）生物力学行为与组织学特征相关信息集合。本研究的核心假设为：经预充气应力作用的尸体腹主动脉瘤壁，是否仍可保持与文献中未受预应力的主动脉相当的抗撕裂性能？

本研究共获取8例腹主动脉瘤标本（6例梭形，2例囊形），经精细解剖后以棉线或普理灵（Prolene）缝线结扎分支血管。每例标本均接受腔内加压直至管壁破裂：通过向标本内置入气囊充气至破裂完成加压流程。从每例标本中采集4份样本：破裂边缘两侧各2份，以及血管近端未扩张区、远端未扩张区各1份作为对照样本，用于单轴拉伸测试与组织学分析。

单轴拉伸测试采用INSTRON SPEC 2200设备，由INSPEC软件与SERIES IX软件协同控制。本次测试测得的变量包括断裂应力、断裂张力与断裂应变。每份样本的测试均生成反映应力-应变关系的曲线图。

组织学分析采用天狼星红（Picrosirius）染色（用于标记胶原纤维）与维尔霍夫（Voerhoeff）染色（用于标记弹性纤维）。遗憾的是部分样本在组织学处理过程中遗失。采用Pannoramic Viewer/Case Viewer.1软件完成胶原与弹性纤维的定量分析。

主要研究发现：即便经拉伸/应力作用至破裂，本研究标本的单轴生物力学特性仍分别与Monteiro与Nynomiya文献中报道的腹主动脉瘤及正常主动脉样本相当[2,3]。

数据说明：
a) 生物力学数据：每份有效测试样本将生成三类文档：1. 应力-应变曲线图；2. 包含应力-应变曲线全部相关数值的Excel表格；3. 生物力学测试软件生成的测试详情报告。所有曲线图的左上角均标注有对应样本的断裂应力、应变与张力。需特别说明的是，部分样本未能生成有效的生物力学测试结果，因此未纳入本数据集。
b) 组织学数据：胶原纤维与弹性纤维的覆盖百分比以十进制小数形式呈现于表I中（例如0.36即代表36%）。与生物力学测试采样规则一致，若条件允许，每例主动脉将采集4份样本。每个病例均包含"histology files"文件夹，内含用于分析的图像（.JPG格式）。

备注：C组病例的组织学样本在处理过程中受损，因此未纳入本数据集。