Genomic profiling of anaplastic meningioma identifies recurrent genetic alterations with relevance to lower-grade meningioma. Genomic profiling of anaplastic meningioma identifies recurrent genetic alterations with relevance to lower-grade meningioma

Genomic profiling of anaplastic meningioma can inform prognostic gene level alterations in lower-grade meningiomas, potentially reflecting evolution of anaplastic meningioma from lowergrade precursor tumours. Larger scale studies in paired primary and recurrent meningiomas are warranted to unravel the evolutionary path to anaplastic meningiomas and prognostic genomic alterations in detail Overall design: Eight cases of anaplastic meningioma with snap frozen tissue underwent RNA sequencing, with approval for the use of human subject material from the Institutional Review Board for the University of Washington

间变性脑膜瘤（anaplastic meningioma）的基因组谱分析，可为低级别脑膜瘤的预后性基因水平改变提供参考，该分析或可揭示间变性脑膜瘤由低级别前驱肿瘤演进的过程。后续需开展更大规模的配对原发与复发脑膜瘤研究，以详细阐明间变性脑膜瘤的演进路径及预后相关基因组改变。本研究整体设计：纳入8例携带速冻组织样本的间变性脑膜瘤病例进行RNA测序（RNA sequencing），相关人体受试者材料的使用已获得华盛顿大学（University of Washington）机构审查委员会（Institutional Review Board）的批准。