Photopromoted Free Radical Silylation of 2‑Aryl‑2H‑indazoles with Silanes

Photoinduced silylation of silanes with 2-aryl-2H-indazoles was developed under mild conditions, which could efficiently result in diverse 3-silylated 2H-indazoles with good substrate scopes. A series of scaled-up to gram level and radical capture operations were performed in this system. Meanwhile, a bioactive molecule was tolerated well under typical conditions.

本研究开发了温和条件下2-芳基-2H-吲唑与硅烷的光诱导硅基化反应，该反应可高效制备多种3-硅基化-2H-吲唑类化合物，且具备优异的底物普适性。本体系中开展了一系列克级规模放大实验与自由基捕获实验，同时，典型反应条件可良好兼容一种生物活性分子。