Donor kidney characteristics and hemodynamics

Current kidney perfusion protocols are not optimized for addressing the ex vivo physiological and metabolic needs of the kidney. Ex vivo normothermic perfusion (EVNP) may be utilized to distinguish high-risk kidneys to determine suitability for transplantation. We assessed the association of tissue metabolic changes with changes in kidney injury biomarkers and functional parameters in eight deceased donor kidneys deemed unsuitable for transplantation during a 12-hour ex vivo normothermic perfusion (EVNP).

当前的肾脏灌注方案尚未针对肾脏的离体生理与代谢需求进行优化。离体常温灌注（Ex vivo normothermic perfusion, EVNP）可用于甄别高风险肾脏，以确定其移植适配性。本研究针对8例经判定不适宜移植的已故供体肾脏，在12小时离体常温灌注过程中，评估了组织代谢变化与肾损伤生物标志物及功能参数变化之间的关联。