RNA sequencing of MEX3A knockdown by siRNA in ovarian cancer cells

RNA-binding proteins can serve as novel potential targets for cancer therapy. We used bioinformatics analysis to screen and identify the key RBPs in ovarian cancer (OC), from which we found that Mex-3 RNA Binding Family Member A (MEX3A) was intimately associated with the clinical prognosis of OC. High expression of MEX3A was involved in the malignant proliferation and aggressiveness of ovarian cancer. The assay was performed on three experimental triplictes of MEX3A knockdown and control ovarian cancer cells.

RNA结合蛋白（RNA-binding proteins）可作为癌症治疗的新型潜在靶点。本研究通过生物信息学分析筛选并鉴定了卵巢癌（OC）中的关键RNA结合蛋白（RBPs），从中发现Mex-3 RNA结合家族成员A（MEX3A）与卵巢癌的临床预后密切相关。MEX3A的高表达参与卵巢癌的恶性增殖与侵袭过程。本实验在MEX3A敲低组与对照组卵巢癌细胞的三组生物学重复中完成。