Comparative genomics of Trypanosoma cruzi I.

Trypanosoma cruzi, the causative agent of Chagas disease shows a marked genetic diversity divided into at least six Discrete Typing Units (DTUs). High intra DTU genetic variability has been observed in the TcI, the most widely distributed DTU, where patterns of genomic diversity can provide information on ecological and evolutionary processes driving parasite population structure and genome organization. Chromosomal aneuploidies and rearrangement across multigene families represent an evidence of T. cruzi genome plasticity. We explored genomic diversity among 18 Colombian T. cruzi I clones.

克氏锥虫 (Trypanosoma cruzi) 是恰加斯病 (Chagas disease) 的病原体，其具有显著的遗传多样性，目前至少可划分为6个离散分型单元 (Discrete Typing Units，DTUs)。在分布范围最广的DTU TcI中，已观测到较高的DTU内遗传变异水平；其基因组多样性模式，可为阐明驱动寄生虫种群结构与基因组组织的生态及进化过程提供参考依据。染色体非整倍性及多基因家族间的重排，均为克氏锥虫基因组可塑性的实证。本研究对18株哥伦比亚克氏锥虫TcI克隆的基因组多样性展开了探究。