Gene expression profile in GSE197748.xlsx

Our research supported preliminary evidence that the regulatory role of the EPAS1/CITED2 axis in the proinflammatory response of macrophages and VSMC apoptosis in AAA is mediated by Am from the gut microbiota.

本研究提供了初步证据，表明EPAS1/CITED2轴（EPAS1/CITED2 axis）在腹主动脉瘤（abdominal aortic aneurysm, AAA）中调控巨噬细胞（macrophages）促炎反应及血管平滑肌细胞（vascular smooth muscle cell, VSMC）凋亡的作用，由肠道菌群（gut microbiota）来源的Am所介导。