Effect of high-fat diet on intestinal mucus barrier-intestinal organoids-RNA-Seq

Excessive dietary fat intake induces microbiota dysbiosis, perturbs nutrient absorption, and alters gut metabolic signaling. Here, we show that high-fat diets not only provide additional energy but also impair glutamine metabolism in goblet cells, leading to reduced mucus production, independent of host genetics.

过量膳食脂肪摄入可诱导微生物群失调，扰乱营养吸收，并改变肠道代谢信号通路。本研究证实，高脂饮食不仅会提供额外能量，还会损伤杯状细胞（goblet cells）内的谷氨酰胺代谢过程，最终导致黏液分泌减少，且该效应不依赖宿主遗传学背景。