Dataset related to article "Testicular Sperm Extraction and Intracytoplasmic Sperm Injection Outcome in Cancer Survivors With No Available Cryopreserved Sperm - Journal of assisted reproduction and genetics"

This record contains data related to article "Testicular sperm extraction and intracytoplasmic sperm injection outcome in cancer survivors with no available cryopreserved sperm".

Objective: To assess rates of successful testicular sperm retrieval and intracytoplasmic sperm injection (ICSI) outcome in cancer survivors affected by non-obstructive azoospermia (NOA) or retrograde ejaculation (RE)/failure of emission (FOE).

Methods: A retrospective analysis of cancer survivors who did not cryopreserve sperm prior to treatment undergoing testicular sperm extraction (TESE). Non-cancer NOA patients and neurologic RE/FOE were the control group.

Results: A total of 97 cancer survivors were offered TESE and 88 (91%) accepted. Sperm was retrieved and cryopreserved in 34/67 patients with NOA (50.7%) and in 21/21 patients affected by RE/FOE (100%). Sperm retrieval rates were similar in the control group (44.9% in NOA and 100% in RE/FOE). The ICSI cumulative pregnancy rate (60%) and live birth rate (40%) per couple in 30 NOA men did not differ from controls (50.0 and 46.5%, respectively; p = 0.399/0.670). The cumulative pregnancy rate (66.7%) and live birth rate (55.6%) in 18 RE/FOE men did not differ from the control group (38.9 and 33.3%, respectively; p = 0.181/0.315). The cancer type and the resulting infertility disorder (NOA or RE/FOE) were not associated with ICSI outcomes. Female partner age was inversely related to the cumulative live birth rate, being fourfold lower (11.5%) in women ≥ 40 years and 48.8% in younger women (p = 0.0037).

Conclusions: The rate of successful TESE and the ICSI outcome in cancer survivors with NOA and RE/FOE is the same as non-cancer azoospermic patients. Female partner age (older than 40 years) was associated with a significant reduction in live birth rates after TESE-ICSI procedures.

本数据集包含与题为"无可用冷冻精子的癌症幸存者的睾丸精子提取术与卵胞浆内单精子注射（intracytoplasmic sperm injection, ICSI）结局"的研究论文相关的数据。

研究目的：评估患有非梗阻性无精子症（non-obstructive azoospermia, NOA）或逆行射精（retrograde ejaculation, RE）/射精失败（failure of emission, FOE）的癌症幸存者的睾丸精子成功获取率，以及ICSI结局。

研究方法：对治疗前未进行精子冷冻保存的癌症幸存者开展睾丸精子提取术（testicular sperm extraction, TESE）并进行回顾性分析。以非癌症性NOA患者及神经性RE/FOE患者作为对照组。

研究结果：共97名癌症幸存者被建议接受TESE，其中88名（91%）同意接受手术。在67名NOA患者中，34名成功获取精子并完成冷冻保存（50.7%）；在21名RE/FOE患者中，全部成功获取精子并完成冷冻保存（100%）。对照组的精子获取率相似：NOA患者为44.9%，RE/FOE患者为100%。在30名NOA男性患者中，每对夫妇的ICSI累积妊娠率为60%、活产率为40%，与对照组（分别为50.0%和46.5%，p=0.399/0.670）无显著差异。在18名RE/FOE男性患者中，累积妊娠率为66.7%、活产率为55.6%，与对照组（分别为38.9%和33.3%，p=0.181/0.315）无显著差异。癌症类型及继发的不育症类型（NOA或RE/FOE）与ICSI结局无关联。女性伴侣年龄与累积活产率呈负相关：年龄≥40岁的女性活产率仅为11.5%，较年轻女性（48.8%）降低四倍（p=0.0037）。

研究结论：患有NOA与RE/FOE的癌症幸存者的TESE成功率及ICSI结局，与非癌症性无精子症患者一致。女性伴侣年龄≥40岁与TESE-ICSI术后活产率的显著降低相关。