MICCAI 2010 : An Anthropomorphic Polyvinyl Alcohol Triple-Modality Brain Phantom based on Colin27

We propose a method for the creation of an anatomically and mechanically realistic brain phantom from polyvinyl alcohol cryogel (PVA-C) for validation of image processing methods for segmentation, reconstruction, registration, and denoising. PVA-C is material widely used in medical imaging phantoms for its mechanical similarities to soft tissues. The phantom was cast in a mold designed using the left hemiphere of the Colin27 brain dataset [Holmes el al. 1998] and contains deep sulci, a complete insular region, and an anatomically accurate left ventricle. Marker spheres and inflatable catheters were also implanted to enable good registration and simulate tissue deformation, respectively. The phantom was designed for triple modality imaging, giving good contrast images in computed tomography, ultrasound, and magnetic resonance imaging. Multimodal data acquired from this phantom are made freely available to the image processing community (http://pvabrain.inria.fr) and will aid in the validation and further development of medical image processing techniques.

本研究提出了一种基于聚乙烯醇冷冻凝胶（polyvinyl alcohol cryogel, PVA-C）制备具备解剖学与力学真实性脑部体模的方法，用于验证分割、重建、配准及去噪等图像处理方法的有效性。聚乙烯醇冷冻凝胶因力学特性与软组织高度相似，已被广泛应用于医学影像体模的制备中。该体模以Colin27脑数据集[Holmes等人，1998年]的左侧半球为蓝本设计模具并浇筑成型，其结构包含深层脑沟、完整的岛叶区域以及解剖学结构精准的左侧侧脑室。研究还植入了标记小球与可充胀导管，分别用于实现精准配准与模拟组织形变。该体模适配三种模态成像，可在计算机断层扫描、超声及磁共振成像中均获得优质的对比图像。本研究将该体模采集得到的多模态数据免费开放给图像处理领域的研究者（访问地址：http://pvabrain.inria.fr），以期助力医学图像处理技术的验证与进一步发展。