TNF-induced Inflammatory Genes Escape Repression in Fibroblast-like Synoviocytes: Transcriptomic and Epigenomic Analysis [ATAC-seq]. TNF-induced Inflammatory Genes Escape Repression in Fibroblast-like Synoviocytes: Transcriptomic and Epigenomic Analysis [ATAC-seq]

Investigated genome-wide changes in gene-expression and chromatin remodeling induced by tumour necrosis factor (TNF) in fibroblast-like synovioctyes (FLS) and macrophages to understand the contribution of FLS to the pathogenesis of rheumatoid arthritis (RA). Overall design: Analysis of transcriptional changes in human RA fibroblast-like synoviocytes (FLS) and macrophages stimulated with or without TNF and I-BET

本数据集旨在阐明成纤维样滑膜细胞（FLS）在类风湿关节炎（RA）发病机制中的贡献，为此探究了肿瘤坏死因子（tumour necrosis factor, TNF）诱导成纤维样滑膜细胞（fibroblast-like synoviocytes, FLS）与巨噬细胞发生的全基因组范围基因表达及染色质重塑变化。实验整体设计：对经TNF与I-BET刺激或未刺激的人类类风湿关节炎（RA）成纤维样滑膜细胞（FLS）及巨噬细胞的转录变化开展分析。