MOESM1 of The effects of bariatric surgery on clinical profile, DNA methylation, and ageing in severely obese patients

Additional file 1: Table S1. Type of the bariatric surgery in 40 severely obese patients. Table S2. Baseline and follow-up characteristics of severely obese cohort before and 12 months after bariatric surgery. Table S3. 4857 significant CpG sites associated with pre- and post bariatric surgery difference form EWAS analysis. Table S4. Correlations of change in DNA methylation with change in clinical measures in pre- and post-surgery cohort. Table S5. Reactome enriched terms based on EWAS results. Table S6. Gene ontology terms enriched based on correlated with clinical traits CpG sites from DAVID software. Table S7. Top 10 gene ontology terms enriched based on correlated with clinical traits CpG sites from Metacore software. Table S8. Top 10 gene-dieseses assotiations enriched based on correlated with clinical traits CpG sites from Metacore software. Table S9. Top 30 trancription factors calculated based on a correlated CpG sites with clinical traits by Metacore software. Table S10. TCF7L1 and LMO2 transcription factore and their associated genes from Metacore software. Table S11. DNA methylation levels significantly associated with gene expression levels from blood derived from publically available data (https://www.genenetwork.nl/biosqtlbrowser/). Table S12. 4857 significant CpG sites associated with pre-and post bariatric surgery difference from EWAS analysis separately for 3 cohorts and a combined effect. Table S13. Characteristics of 2 Lifelines subcohorts, healthy lean and healthy obese.

附加文件1：表S1。40例重度肥胖患者的减重代谢手术类型。
表S2。重度肥胖队列在减重代谢手术前及术后12个月的基线与随访特征。
表S3。来自全表观基因组关联分析（Epigenome-Wide Association Study，EWAS）的、与减重代谢手术前后差异相关的4857个显著性CpG位点。
表S4。手术前后队列中DNA甲基化变化与临床指标变化的相关性。
表S5。基于EWAS分析结果的Reactome富集条目。
表S6。通过DAVID软件对与临床性状相关的CpG位点进行富集分析得到的基因本体（Gene Ontology，GO）条目。
表S7。通过Metacore软件对与临床性状相关的CpG位点进行富集分析得到的前10个基因本体条目。
表S8。通过Metacore软件对与临床性状相关的CpG位点进行富集分析得到的前10个基因-疾病关联条目。
表S9。通过Metacore软件对与临床性状相关的CpG位点进行分析得到的前30个转录因子。
表S10。来自Metacore软件的TCF7L1与LMO2转录因子及其关联基因。
表S11。来自公开数据集（https://www.genenetwork.nl/biosqtlbrowser/）的、与血液来源基因表达水平显著相关的DNA甲基化水平数据。
表S12。来自全表观基因组关联分析的、与减重代谢手术前后差异相关的4857个显著性CpG位点，分别针对3个队列及合并效应进行分析。
表S13。2个Lifelines亚队列的特征：健康瘦体型个体与健康肥胖个体。