Expression data from murine lung derived alveolar macrophages

Lung alveolar macrophages are self-renewing tissue resident macrophages primarily relying upon GM-CSF signal as a main source. We used microarrays to detail the global programme of gene expression underlying homeostasis and functions of alveolar macrophages in absence of phosphatase Ssu72 Alveolar macrophages were sorted from Lysm-Cre mice and Lysm-CreSsu72fl/fl mice

肺肺泡巨噬细胞（lung alveolar macrophages）是一类自我更新的组织驻留巨噬细胞，其主要以粒细胞-巨噬细胞集落刺激因子（GM-CSF）信号作为核心生存依赖来源。本研究通过基因芯片（microarrays）技术，详细解析了磷酸酶Ssu72缺失条件下，肺泡巨噬细胞稳态与功能背后的全局基因表达调控程序。实验所用肺泡巨噬细胞均从Lysm-Cre小鼠与Lysm-CreSsu72fl/fl小鼠体内分选得到。