Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Descriptor: 6-ethyl-4-methoxy-2-(pyridin-3-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde, Topoisomerase IV, subunit B Authors: Bensen, D.C, Creighton, C.J, Kwan, B, Tari, L.W. Deposit date: 2012-11-12 Release date: 2013-02-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013

《DNA旋转酶B（DNA gyrase B, GyrB）与拓扑异构酶IV（topoisomerase IV, ParE）的吡咯并嘧啶（Pyrrolopyrimidine）抑制剂 第一部分：兼具强效广谱酶活性的双靶向剂的结构导向发现与优化》。描述项：6-乙基-4-甲氧基-2-(吡啶-3-基硫基)-7H-吡咯并[2,3-d]嘧啶-5-甲醛、拓扑异构酶IV B亚基。作者：Bensen, D.C.、Creighton, C.J.、Kwan, B.、Tari, L.W.。提交日期：2012-11-12。发布日期：2013-02-13。最后修改日期：2024-02-28。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.7埃）。引用文献：《DNA旋转酶B（GyrB）与拓扑异构酶IV（ParE）的吡咯并嘧啶抑制剂 第一部分：兼具强效广谱酶活性的双靶向剂的结构导向发现与优化》，《生物有机与药物化学快报》，2013年，第23卷。