Replication Data For \"Neurocognitive Impairment Among Cryptococcal Meningitis Survivors in Uganda, a Prospective Cohort Study\"

Neurocognitive impairment in HIV-associated cryptococcal meningitis survivors remains poorly characterized. We sought to identify risk factors associated with sustained neurocognitive impairment. Cryptococcal meningitis survivors from the ASTRO-CM trial underwent neurocognitive assessment at 12 weeks. A composite quantitative neurocognitive performance score (QNPZ-8) was calculated as a mean of 8 independent z-scores. Participants were classified by QNPZ-8 score as having mild (QNPZ-8 ≥−1), moderate (−2 < QNPZ-8 < –1), or severe (QNPZ-8 ≤−2) impairment compared with the reference cohort of HIV-negative Ugandan adults. We compared differences in baseline demographics and clinical and laboratory variables by impairment categories. One hundred fifty-two participants completed ≥5 of the 8 neuropsychological tests and were included in the analysis. Overall, 37% (57/152) exhibited mild (QNPZ-8 ≥−1), 37% (56/152) moderate (−2 < QNPZ-8 < –1), and 26% (39/152) severe impairment (QNPZ-8 ≤−2). The overall mean QNPZ-8 score (SD) of −1.4 (0.82) denoted moderate neurocognitive impairment at 12 weeks. At baseline, lower weight (P = .03), Glasgow Coma Scale score <15 (P = .03), and education ≤7 years (P < .001) were more frequently observed among those with severe neurocognitive impairment at 12 weeks. Education ≤7 years (odds ratio, 6.13; 95% CI, 2.96–12.68; P < .001) and Glasgow Coma Scale score <15 (odds ratio, 2.61; 95% CI, 1.23–5.57; P = .013) were associated with moderate or severe neurocognitive impairment.

HIV相关隐球菌性脑膜炎幸存者的神经认知障碍特征仍不明确。本研究旨在确定与持续性神经认知障碍相关的风险因素。来自ASTRO-CM试验的隐球菌性脑膜炎幸存者在12周时接受了神经认知评估。综合定量神经认知表现评分（QNPZ-8）计算为8个独立z分数的平均值。与HIV阴性乌干达成人参考队列相比，参与者根据QNPZ-8评分分为轻度（QNPZ-8 ≥−1）、中度（−2 < QNPZ-8 < –1）或重度（QNPZ-8 ≤−2）障碍。我们比较了不同障碍类别之间基线人口统计学、临床和实验室变量的差异。152名参与者完成了8项神经心理学测试中的≥5项，并被纳入分析。总体而言，37%（57/152）表现为轻度（QNPZ-8 ≥−1）、37%（56/152）中度（−2 < QNPZ-8 < –1）和26%（39/152）重度障碍（QNPZ-8 ≤−2）。12周时总体平均QNPZ-8评分（标准差）为−1.4（0.82），表明存在中度神经认知障碍。基线时，在12周时存在重度神经认知障碍的参与者中，体重较低（P = .03）、格拉斯哥昏迷量表（Glasgow Coma Scale）评分<15（P = .03）和教育年限≤7年（P < .001）更为常见。教育年限≤7年（比值比6.13；95%置信区间2.96–12.68；P < .001）和格拉斯哥昏迷量表评分<15（比值比2.61；95%置信区间1.23–5.57；P = .013）与中度或重度神经认知障碍相关。