Dearomatization-Induced Cycloaddition and Aromatization-Triggered Rearrangement: Synthesis of Vertically Expanded Five-Ring Fused Benzofurans

A dearomatization strategy has been developed for the efficient construction of vertically expanded five-ring fused benzofurans from ortho-alkynylphenols and ortho-alkynylarylaldimines. The stepwise procedure comprises a dearomatization-induced silver-catalyzed [3 + 2] cycloaddition followed by an aromatization-triggered ytterbium-catalyzed rearrangement.

本研究开发了一种脱芳构化策略，可从邻炔基苯酚与邻炔基芳基醛亚胺高效构建垂直扩环的五环稠合苯并呋喃类化合物。该分步反应过程依次包含脱芳构化诱导的银催化[3+2]环加成反应，以及芳构化触发的镱催化重排反应。