T. pallidum protein-encoding genes with the highest average FPKM during in vitro culture or rabbit infection.

The fifty genes with the highest gene expression based on average FPKM during in vitro culture and rabbit infection are listed in order from highest expression to lowest in the rabbit-derived specimens. ORF numbers in black indicate that the gene is one of the fifty most highly-expressed genes during both rabbit infection and in vitro culture. indicate that the gene is one of the fifty most highly-expressed genes in rabbits but not in vitro culture, while indicate indicate that the gene is one of the fifty most highly-expressed during in vitro culture, but not in rabbit infection. Average FPKM was calculated based on counts determined by HTSeq with the minimum alignment quality set to 0 and excluding rRNA and tRNA read pairs. Unless otherwise indicated, functional categories based on [26].

本数据集收录了体外培养与家兔感染过程中，基于平均FPKM（Fragments Per Kilobase of transcript per Million mapped reads）计算得到的表达量最高的50个基因，排序依据为家兔来源样本中的基因表达水平从高到低排列。黑色标注的ORF编号表明该基因在兔感染与体外培养两种条件下均属于表达量最高的50个基因；[原文缺失对应标记说明]表明该基因仅在家兔感染样本中位列高表达前50，而非体外培养样本；而[原文另一缺失的标记说明]表明该基因仅在体外培养过程中位列高表达前50，而非家兔感染样本。平均FPKM值基于HTSeq工具统计得到的计数结果计算，计算时将最低比对质量阈值设为0，并剔除核糖体RNA（rRNA）与转运RNA（tRNA）的读段对。除非另有说明，基因功能分类依据文献[26]。