Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones

Silicon amine protocol (SLAP) reagents for photocatalytic cross-coupling with aldehydes and ketones to form N-unprotected piperazines have been developed. This blue light promoted process tolerates a wide range of heteroaromatic, aromatic, and aliphatic aldehydes and structurally and stereochemically complex SLAP reagents. It provides a tin-free alternative to SnAP (tin amine protocol) reagents for the synthesis of substituted piperazines.

已开发出可与醛、酮进行光催化交叉偶联以制备未保护哌嗪的硅胺操作规程（Silicon Amine Protocol, SLAP）试剂。该蓝光促进的反应体系可兼容多种杂芳族、芳族及脂肪族醛，以及结构与立体化学均复杂的SLAP试剂。本方法为采用锡胺操作规程（SnAP）试剂合成取代哌嗪的路径提供了无锡替代方案。