Additional file 2 of A gene-signature progression approach to identifying candidate small-molecule cancer therapeutics with connectivity mapping

Significant drugs returned with the k=50 HDACi gene signature. The list of significant drugs returned from sscMap using the k=50 HDACi gene signature from the â simulated experimentâ . All 7 known HDAC inhibitors were pulled out, but together with many other drugs, which may or may not related to HDAC inhibition. The main biological theme (HDAC inhibition) could potentially be weakned or even masked due to the co-existence of many other drugs. (XLSX 17 kb)

基于k=50组蛋白去乙酰化酶抑制剂（HDACi）基因特征集返回的显著关联药物集合。本数据集包含通过sscMap工具，利用来自模拟实验的k=50 HDACi基因特征集所得到的显著药物列表。该列表囊括全部7种已报道的HDAC抑制剂，同时伴随大量或与HDAC抑制作用相关、或无关的其他药物。由于大量非关联药物的共存，核心生物学主题（HDAC抑制作用）有可能被弱化，甚至完全被掩盖。（XLSX 17 kb）