CITE-seq ex vivo engineered human plasma cells . CITE-seq ex vivo engineered human plasma cells

Due to their unique longevity and capacity to secrete high levels of protein, plasma B cells play have the potential to be used as a cell therapy for protein replacement. Here, we show that ex vivo engineered human plasma cells exhibited transcriptional features of long-lived plasma cells. Overall design: Ex vivo differentiated B cells day 7 and day13.

鉴于浆细胞（plasma B cells）独特的长寿特性与高水平蛋白分泌能力，其具备用作蛋白替代治疗的细胞疗法的潜力。本研究证实，体外（ex vivo）工程化改造的人源浆细胞，呈现出长寿浆细胞的转录特征。实验整体设计：体外诱导分化第7天与第13天的B细胞。