Additional file 2: of The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression

Associations of arsenic exposure with candidate developmental/stemness and arsenic metabolism/transport genes, with and without adjustment for urinary specific gravity. Multivariable linear regression analyses were performed to determine the association of U-As levels with developmental/stemness gene expression in female (sheet 1) or male (sheet 2) fetal placenta, with or without adjustment for urinary specific gravity as indicated. All analyses were adjusted for maternal age. Genes showing differences in coefficient estimates between models of greater than one standard error are highlighted in yellow. (XLSX 72Â kb)

本研究分析了砷暴露与候选发育/干细胞特性基因、砷代谢/转运基因的关联，分别设置校正尿比重与不校正尿比重两种分析方案。采用多元线性回归模型，探究女性（工作表1）或男性（工作表2）胎儿胎盘中尿砷（U-As，Urinary Arsenic）水平与发育/干细胞特性基因表达的关联，并根据标注要求选择是否校正尿比重。所有分析均校正了母亲年龄这一混杂因素。在不同分析模型间系数估计值差异大于1个标准误的基因，将以黄色高亮标注。（XLSX格式，72 KB）