Effect of dexmedetomidine combined with the modified Trendelenburg position on intraocular pressure in patients undergoing robot-assisted laparoscopic surgery

A total of 160 patients scheduled for robot-assisted laparoscopic surgery were randomly assigned to four groups: the control group receiving normal saline and traditional positioning (NT group), the modified Trendelenburg position group (NM group), the dexmedetomidine group (DT group), and the dexmedetomidine-modified Trendelenburg position group (DM group). Intraocular pressure (IOP) was measured at baseline (T0), 2 minutes after anesthesia induction (T1), 0.5, 1.5, and 2.5 hours after CO2 pneumoperitoneum (T2, T3, T4), and 2 minutes after extubation (T5). The incidence of adverse cardiovascular events, the utilization rate of vasoactive drugs, and complications related to intraocular hypertension (such as ocular swelling, ocular pain, nausea, vomiting, dizziness, and headache) within 24 hours after surgery were recorded.

本研究共纳入160例拟行机器人辅助腹腔镜手术的患者，采用随机分配原则分为四组：予以生理盐水联合传统体位的对照组（NT组）、改良特伦德伦伯卧位（modified Trendelenburg position）组（NM组）、右美托咪定组（DT组）以及右美托咪定联合改良特伦德伦伯卧位组（DM组）。分别于基线状态（T0）、麻醉诱导后2分钟（T1）、CO₂气腹建立后0.5小时、1.5小时、2.5小时（T2、T3、T4）以及拔管后2分钟（T5）测定患者的眼压（intraocular pressure，IOP）。记录患者术后24小时内心血管不良事件发生率、血管活性药物使用率，以及与眼内压升高相关的并发症（如眼胀、眼痛、恶心、呕吐、头晕及头痛）的发生情况。