Ternary structure of 14-3-3s, C-RAF phosphopeptide 12-mer (pS259) and compound 78 (1084378)

Ternary structure of 14-3-3s, C-RAF phosphopeptide 12-mer (pS259) and compound 78 (1084378) Descriptor: 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone, 14-3-3 protein sigma, CALCIUM ION, ... Authors: Konstantinidou, M, Vickery, H, Pennings, M.A.M, Virta, J, Visser, E.J, Oetelaar, M.C.M, Overmans, M, Neitz, J, Ottmann, C, Brunsveld, L, Arkin, M.R. Deposit date: 2024-04-03 Release date: 2025-04-16 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Modulation of the 14-3-3 sigma /C-RAF "Auto"inhibited Complex by Molecular Glues. J.Am.Chem.Soc., 148, 202614-3-3蛋白（14-3-3）、C-RAF磷酸肽12聚体（pS259）与化合物78（1084378）的三元复合物结构。描述项：1-[8-(4-溴苯基)磺酰基-5-氧杂-2,8-二氮杂螺[3.5]壬烷-2-基]-2-氯乙酮、14-3-3σ蛋白、钙离子等。作者：Konstantinidou M、Vickery H、Pennings M.A.M、Virta J、Visser E.J、Oetelaar M.C.M、Overmans M、Neitz J、Ottmann C、Brunsveld L、Arkin M.R。提交日期：2024-04-03；发布日期：2025-04-16；最后修订日期：2026-03-04。测试方法：X射线衍射（分辨率1.4埃）。引用：《分子胶调控14-3-3σ/C-RAF"自发"抑制复合物》，《美国化学会志（J.Am.Chem.Soc.）》，第148卷，2026年。