Appendix containing extended methods and supplementary tables and figures pertaining to the manuscript

In this study, we treated phylogenetically diverse Mycobacterium tuberculosis clinical strains to 65 unique drug combinations in two different host-like <i>in vitro</i> conditions. We observed a broad range of drug response phenotypes across the strains, with the most effective drug combinations varying greatly by strain and metabolic condition.

本研究中，我们对系统发育多样性各异的结核分枝杆菌（Mycobacterium tuberculosis）临床菌株，在两种不同的宿主样体外（in vitro）培养条件下，采用65种独特的药物组合进行处理。我们在各类菌株中观测到了范围广泛的药物反应表型，且最有效的药物组合会随菌株与代谢状态的不同而呈现显著差异。