S1 File - Acute Endovascular Reperfusion Therapy in Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Appendix A: PubMed search Strategy. Appendix B: Grading Quality of the Evidence and Recommendations. Table A: PRISMA Checklist. Table B: GRADE evaluation of quality of evidence. Table C: List of excluded studies. Figure A: Cumulative meta-analysis (i.e. effects over time). Figure B: Forest plots showing any intracranial hemorrhage between endovascular therapy and controls. Figure C: Forest plot showing mortality in endovascular therapy vs controls. Figure C1: IA thrombolysis only vs mechanical device use. Figure C2: Comparator includes IV thrombolysis vs no thrombolysis. Figure C3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure D: Forest plot showing any intracranial hemorrhage in endovascular therapy vs controls. Figure D1: IA thrombolysis only vs mechanical device use. Figure D2: Comparator includes IV thrombolysis vs no thrombolysis. Figure D3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure E: Forest plot showing symptomatic intracranial hemorrhage in endovascular therapy vs controls. Figure E1: IA thrombolysis only vs mechanical device use. Figure E2: Comparator includes IV thrombolysis vs no thrombolysis. Figure E3: Studies that required vessel occlusion vs studies did not require vessel occlusion status. Figure F: Funnel Plots and Egger’s test for asymmetry of the funnel plot (p (DOCX)

附录A：PubMed检索策略。
附录B：证据质量分级与推荐意见。
表A：PRISMA检查表（PRISMA Checklist）。
表B：GRADE证据质量评价表。
表C：排除研究列表。
图A：累积荟萃分析（即随时间变化的效应量）。
图B：森林图，展示血管内治疗组与对照组的任何颅内出血发生情况。
图C：森林图，展示血管内治疗组与对照组的死亡率。
图C1：仅动脉内溶栓组 vs 机械取栓装置使用组。
图C2：对照组为静脉溶栓组 vs 无溶栓组。
图C3：要求提供血管闭塞状态的研究 vs 未要求提供血管闭塞状态的研究。
图D：森林图，展示血管内治疗组与对照组的任何颅内出血发生情况。
图D1：仅动脉内溶栓组 vs 机械取栓装置使用组。
图D2：对照组为静脉溶栓组 vs 无溶栓组。
图D3：要求提供血管闭塞状态的研究 vs 未要求提供血管闭塞状态的研究。
图E：森林图，展示血管内治疗组与对照组的症状性颅内出血发生情况。
图E1：仅动脉内溶栓组 vs 机械取栓装置使用组。
图E2：对照组为静脉溶栓组 vs 无溶栓组。
图E3：要求提供血管闭塞状态的研究 vs 未要求提供血管闭塞状态的研究。
图F：漏斗图及Egger检验，用于评估漏斗图不对称性（p (DOCX)）。