Erratum: Significant Associations between CCL5 Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients

Background: Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific CCL5 gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between CCL5 gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. Methods: A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the CCL5 gene were genotyped from genomic DNA with direct sequencing. Results: PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of CCL5 gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the CCL5 gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. Conclusions: Our results indicated that genetic polymorphisms of the CCL5 gene were associated with PTDM, suggesting that the CCL5 gene might confer susceptibility to PTDM in patients who receive renal transplants.

背景：移植后糖尿病（Post-transplantational diabetes mellitus, PTDM）是肾移植术后可能发生的严重代谢并发症。趋化因子（C-C基序）配体5（chemokine (C-C motif) ligand 5, CCL5）的表达水平与胰腺β细胞功能呈负相关，因此特定的CCL5基因多态性被视为糖尿病的危险因素。本研究针对韩国肾移植患者，探讨CCL5基因多态性与PTDM发生的关联。方法：本研究共纳入311例既往无糖尿病病史的肾移植受者。采用直接测序法对基因组DNA中的CCL5基因3个单核苷酸多态性（single nucleotide polymorphism, SNP）位点进行基因分型。结果：共有56例患者（占比18.0%）发生了PTDM。分析结果显示，PTDM患者的CCL5基因多态性位点rs2107538*T、rs2280789*C及rs3817655*A的等位基因频率显著高于未发生PTDM的患者。多因素logistic回归分析表明，在共显性2模型及隐性模型中，CCL5基因的3个SNP位点（rs2107538、rs2280789及rs3817655）均与PTDM的发生显著相关。在上述3个多态性位点的单体型中，TCA单体型在PTDM患者中的出现频率显著高于未发病患者。结论：本研究结果证实CCL5基因的遗传多态性与PTDM存在显著关联，提示CCL5基因可能会增加肾移植受者罹患PTDM的遗传易感性。