SNPs with cell-type-specific AEI associated with HbA1c in the Fadista data when the Baron data were used as reference.

We applied BSCET to the Fadista pancreatic islets bulk RNA-seq data [15] using the MuSiC [14] proportion estimates obtained from the Baron single-cell reference [12]. We detected 5 SNPs in 4 genes with cell-type-specific AEI significantly associated with HbA1c (FDR adjusted P-value (XLSX)

我们将BSCET应用于Fadista胰岛批量RNA测序（bulk RNA-seq）数据集[15]，采用从Baron单细胞参考数据集[12]中获取的MuSiC [14]细胞比例估计值开展分析。本研究在4个基因中检测到5个单核苷酸多态性（Single Nucleotide Polymorphism，SNPs），其细胞类型特异性等位基因特异性表达（Allele-specific Expression，AEI）与糖化血红蛋白（Hemoglobin A1c，HbA1c）显著相关，相关统计检验的P值经错误发现率（False Discovery Rate，FDR）校正，完整数据以XLSX格式存储。