Table 1_Statistical analysis of the measured strength parameters of the fresh main intracranial arteries.docx

This study presents the strength parameters of the major intracranial arteries: basilar artery (BA), anterior cerebral arteries (ACA), both left (LACA) and right (RACA), and middle cerebral arteries (MCA), both left (LMCA) and right (RMCA) and the anterior communicating artery (ACoA) obtained by performing single rupture tensile tests on fresh human biological specimens. The measured parameters included maximum Young’s modulus, E, ultimate strength, Rm, rupture strength, Ru, and rupture strain, A, allowing the determination of mean values for each artery type. They were also the basis for a multiple comparison analysis showing that ACA and ACoA significantly differ from BA and MCA. The study also showed that the measured strength parameters are directly dependent on the thickness of the arterial wall, and this effect is about 4–5 times greater for the ACA group and 1.5–3 times greater for ACoA than in the BA + MCA group. Finally, a limit value of maximum relative longitudinal strain of 7% was proposed at low risk of rupture during neurovascular procedures. Obtained parameters and findings have potential applications in optimizing neurointerventional devices, tissue engineering of arterial phantoms or tissue scaffolds, and computational simulations in cerebral hemodynamics.

本研究针对数种主要颅内动脉的强度参数进行了测定，实验对象涵盖基底动脉（BA）、大脑前动脉（ACA）（含左大脑前动脉LACA与右大脑前动脉RACA）、大脑中动脉（MCA）（含左大脑中动脉LMCA与右大脑中动脉RMCA）以及前交通动脉（ACoA），所有数据均通过对新鲜人体生物标本开展单轴破裂拉伸试验获取。本次测定的力学参数包括最大杨氏模量（E）、极限强度（Rm）、破裂强度（Ru）与破裂应变（A），据此可计算得到每种动脉类型的平均参数值。通过多重比较分析证实，大脑前动脉与前交通动脉的强度参数显著区别于基底动脉与大脑中动脉。研究同时发现，所测得的强度参数与动脉管壁厚度呈直接相关性：大脑前动脉组的相关效应强度约为基底动脉+大脑中动脉组的4~5倍，前交通动脉组则为该组的1.5~3倍。最后本研究提出，在神经血管手术中，当最大相对纵向应变达到7%时，动脉破裂风险处于较低水平。本研究所得参数与研究结论，可用于优化神经介入器械、动脉假体组织工程或组织支架研发，以及脑血流动力学计算模拟等相关场景。