Raw data.xlsx

Twelve month old Wistar-Han rats (n=15) were fed a 60% fat diet for 8 months and serial blood samples were taken to assess the development of metabolic syndrome and pro-inflammatory markers. Following this, to pilot the suitability of these rats for undergoing surgical models of stroke, they underwent 30min of middle cerebral artery occlusion (MCAO) alongside younger controls fed a standard diet (n=10). Survival, weight and functional outcome were monitored and blood vessels and tissues collected for analysis. <br>Attached data is body weight over 8 months, random glucose, fasted glucose, metabolic markers (C-peptide, Insulin, Leptin), inflammatory markers and cytokines over 8 months on the high fat diet. Blood pressure, arterial wall thickness, liver vacuole size, body weight after MCAO, infarct volume. For methods details see linked manuscript.

12月龄Wistar-Han大鼠（n=15）被饲喂60%脂肪含量的饲料8个月，期间采集系列血液样本，以评估其代谢综合征（metabolic syndrome）及促炎标志物的动态变化。随后为试点验证该类大鼠是否适用于脑卒中手术模型，对其实施30分钟大脑中动脉闭塞（middle cerebral artery occlusion, MCAO）造模，并设置饲喂标准饲料的年轻对照组（n=10）。实验过程中监测大鼠的存活率、体重与功能结局，并采集血管及组织样本用于后续分析。
本次附带数据集涵盖：高脂饲料饲喂8个月期间的体重变化、随机血糖、空腹血糖、代谢标志物（C肽、胰岛素、瘦素）、炎症标志物与细胞因子水平；此外还包含血压、动脉管壁厚度、肝空泡大小、大脑中动脉闭塞术后的体重变化及脑梗死体积。详细实验方法参见所关联的手稿。