Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).

Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid). Descriptor: 1,2-ETHANEDIOL, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Srikannathasan, V, Johansson, C, Gileadi, C, Kopec, J, Strain-Damerell, C, Kupinska, K, BurgessBrown, N.A, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Oppermann, U. Deposit date: 2015-06-02 Release date: 2015-06-17 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016

本数据集收录了人类PLU-1（JARID1B）与KDM5-C49以及配体2-(((2-((2-(二甲基氨基)乙基)(乙基)氨基)-2-氧代乙基)氨基)甲基)异烟酸形成复合物的晶体结构。配体组分描述：1,2-乙二醇（1,2-ETHANEDIOL）、2-{[(2-{[(E)-2-(二甲基氨基)乙烯基](乙基)氨基}-2-氧代乙基)氨基]甲基}吡啶-4-羧酸、4-(2-羟乙基)-1-哌嗪乙磺酸（4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID）等。作者：Srikannathasan, V、Johansson, C、Gileadi, C、Kopec, J、Strain-Damerell, C、Kupinska, K、Burgess-Brown, N.A、von Delft, F、Arrowsmith, C.H、Bountra, C、Edwards, A.M、Oppermann, U。提交日期：2015-06-02；发布日期：2015-06-17；最后修订日期：2026-03-04。实验方法：X射线衍射（分辨率1.9埃）。引用文献：《人类Kdm5B的结构分析指导组蛋白去甲基化酶抑制剂开发》（Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development），发表于《自然·化学生物学（Nat.Chem.Biol.）》2016年，第12卷。