Iodine(III)-Mediated Umpolung of Bromide Salts for the Ethoxybromination of Enamides

Using (diacetoxyiodo)benzene in conjunction with simple bromide salts in ethanol allows the regioselective ethoxybromination of a wide range of enamides, thus yielding highly versatile α-bromo hemiaminals, which can then be engaged in a broad array of transformations.

在乙醇溶剂中，将二乙酰氧基碘苯（(diacetoxyiodo)benzene）与简单溴化物盐联用，可实现多种烯酰胺的区域选择性乙氧基溴化反应，从而得到通用性极强的α-溴代半缩醛胺，该类产物可进一步参与多种转化反应。