Intrauterine Microbiota in Chronic Endometritis Patients Based on 16s rRNA sequencing Analysis

Chronic endometritis (CE) is a disease of continuous and subtle inflammation occurred in the endometrial stromal area, which is often asymptomatic or present with non-specific clinical symptoms. This study investigated the composition and distribution of the intrauterine microbiota of 71 patients who underwent hysteroscopy during the routine clinical inspection of infertility. Among them, patients who diagnosed as chronic endometritis (CE) were allocated into CE group (n = 29) and others into non-CE group (n = 42).

慢性子宫内膜炎（Chronic Endometritis, CE）是一类发生于子宫内膜间质区域的持续性隐匿性炎症性疾病，通常无明显临床症状或仅表现为非特异性临床表现。本研究针对不孕症常规临床检查中接受宫腔镜检查（hysteroscopy）的71例患者，对其宫内微生物群（intrauterine microbiota）的组成与分布情况进行了探究。其中，确诊为慢性子宫内膜炎（CE）的患者被纳入CE组（n=29），其余患者则被归入非CE组（n=42）。