Transcriptome sequencing of zebrafish mutants with or without Edwardsiella tarda infection

To investigate the possible mechanism that NOD1/RIP2 impacts larval survival in zebrafish under infectious condition, we performed transcriptome analysis. Zebrafish larvae from WT, NOD1-/- and RIP-/- were infected with Edwardsiella tarda, and collected at 24 hours post-infection (hpi).

为探究NOD1/RIP2在感染条件下影响斑马鱼幼鱼存活的潜在机制，本研究开展了转录组分析。选取野生型（Wild Type, WT）、NOD1基因敲除（NOD1-/-）及RIP基因敲除（RIP-/-）的斑马鱼幼鱼，以迟钝爱德华氏菌（Edwardsiella tarda）进行感染，并于感染后24小时（hpi）采集样本。