Enantioselective Synthesis of the 5–6–7 Carbocyclic Core of the Gagunin Diterpenoids

A catalytic enantioselective double allylic alkylation reaction has been employed in the synthesis of the core of the gagunin diterpenoids. Enantioenriched material was advanced in 11 steps to afford the core of the highly oxygenated target, which includes two all-carbon quaternary stereocenters.

催化对映选择性双烯丙基烷基化反应（catalytic enantioselective double allylic alkylation）已被应用于gagunin二萜类化合物（gagunin diterpenoids）的核心骨架合成。研究以对映富集的原料为起始，经11步反应得到该高氧化态目标产物的核心骨架，该骨架包含两个全碳季碳立体中心（all-carbon quaternary stereocenters）。