Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection. Mus musculus

Childhood malaria is a risk factor for disseminated infections with non-typhoidalSalmonella (NTS) serotypes in sub-Saharan Africa. It is not known whether malaria affects colonization resistance of the host to NTS. To address this question, this study utilized a murine model of concurrent infection withPlasmodium yoelii nigeriensis (P. yoelii) and NTS.

在撒哈拉以南非洲地区，儿童疟疾是非伤寒沙门氏菌（non-typhoidal Salmonella, NTS）血清型播散性感染的危险因素。目前尚不明确疟疾是否会影响宿主对NTS的定植抵抗力。为解答这一科学问题，本研究采用约氏疟原虫尼日尔亚种（Plasmodium yoelii nigeriensis, P. yoelii）与NTS共感染的小鼠模型开展实验。