S. pombe wild type strains genomes

Most fission yeast researchers use strains derived from Leupoldâ??s 972 isolate and that was the strain sequenced by the Sanger Institute and defining the reference genome for S. pombe. However, in strain collections all over the world there are over 100 different wild isolates not related to Leupoldâ??s 972 isolate. To date nothing is known about the natural variability existing in wild S. pombe populations. This project aims to sequence 8 new strains of S. pombe and provides insight into the S. pombe variability.

绝大多数裂殖酵母（fission yeast）领域的科研人员所使用的菌株，均源自莱普尔德（Leupold）的972分离株；该分离株由桑格研究所（Sanger Institute）完成测序，同时作为粟酒裂殖酵母（S. pombe）的参考基因组标准菌株。然而，全球各地的菌株保藏库中，存有超过100株与莱普尔德972分离株无亲缘关联的野生分离株。截至目前，学界对于粟酒裂殖酵母野生种群中存在的自然遗传变异仍缺乏认知。本项目拟对8株全新的粟酒裂殖酵母菌株进行测序，旨在深入解析该物种的遗传变异特征。