CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH O=C(NC1COC1)c1cc2[nH]c(-c3ccccc3)nc2cc1NC(=O)c1cc(C2CC2)c[nH]c1=O, micromolar IC50=0.012286

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH O=C(NC1COC1)c1cc2[nH]c(-c3ccccc3)nc2cc1NC(=O)c1cc(C2CC2)c[nH]c1=O, micromolar IC50=0.012286 Descriptor: 5-[(5-cyclopropyl-2-oxo-1,2-dihydropyridine-3-carbonyl)amino]-N-(oxetan-3-yl)-2-phenyl-1H-benzimidazole-6-carboxamide, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Bleicher, K, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.66 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人类磷酸二酯酶10与配体O=C(NC1COC1)c1cc2[nH]c(-c3ccccc3)nc2cc1NC(=O)c1cc(C2CC2)c[nH]c1=O复合物的晶体结构，其半最大抑制浓度（IC50）为0.012286微摩尔。描述符：5-[(5-环丙基-2-氧代-1,2-二氢吡啶-3-羰基)氨基]-N-(氧杂环丁烷-3-基)-2-苯基-1H-苯并咪唑-6-甲酰胺、镁离子、锌离子等。作者：Joseph, C、Benz, J、Flohr, A、Bleicher, K、Rudolph, M.G.。入库日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16。实验方法：X射线衍射（分辨率2.66埃）。引用文献：《人类磷酸二酯酶10复合物晶体结构》待发表。