Prognostic value and immune role of IGFL2 in bladder urothelial carcinoma

Objective To explore the prognostic value and immune effect of IFGL2 in bladder cancer.Methods Bioinformatics analysis was used to analyze the expression of IGFL2 in bladder cancer and its relationship with survival and prognosis of bladder cancer patients. ROC curves and prognostic nomograms were used to analyze the diagnostic value of IGFL2 in bladder cancer and predict the 5-year overall survival rate of individuals. IGFL2-related signaling pathways were analyzed by GSEA enrichment. The correlation between IGFL2 expression levels and immune cells was analyzed from the TIMER database.Results IGFL2 was highly expressed in bladder cancer. The high expression of IGFL2 was positively correlated with age, pathological stage, histological grade and T stage. The overall survival and disease-specific survival of the IGFL2 high expression group were worse than those of the low IGFL2 expression group. IGFL2 can be used as an independent prognostic factor for bladder cancer and has good diagnostic and predictive value. GSEA enrichment analysis showed that IGFL2 was involved in signaling pathways related to immunity, inflammation and tumor. High IGFL2 expression was positively correlated with the level of infiltration of most immune cells.Conclusion IGFL2 is highly expressed in bladder cancer patients, which is a biomarker for the diagnosis and prognosis of bladder cancer, and may become a potential target for immunotherapy.

研究目的：探讨IGFL2在膀胱癌中的预后价值与免疫效应。
研究方法：采用生物信息学分析方法，解析IGFL2在膀胱癌中的表达水平及其与膀胱癌患者生存及预后的关联；通过ROC曲线及预后列线图分析IGFL2对膀胱癌的诊断价值，并预测个体的5年总生存率；通过GSEA富集分析探究IGFL2相关信号通路；从TIMER数据库中分析IGFL2表达水平与免疫细胞的相关性。
研究结果：IGFL2在膀胱癌组织中呈高表达状态；IGFL2高表达与患者年龄、病理分期、组织学分级及T分期呈正相关；IGFL2高表达组患者的总生存期及疾病特异性生存期均劣于IGFL2低表达组；IGFL2可作为膀胱癌的独立预后因子，且具备良好的诊断与预测价值；GSEA富集分析结果显示，IGFL2参与免疫、炎症及肿瘤相关信号通路；IGFL2高表达与多数免疫细胞的浸润水平呈正相关。
研究结论：IGFL2在膀胱癌患者中呈高表达状态，可作为膀胱癌诊断与预后的生物标志物，或有望成为免疫治疗的潜在靶点。