Preservation of fecal microbiome is associated with reduced severity of Graft-versus-Host Disease

Patterns of microbial dysbiosis can be detected in fecal samples of GI-aGVHD patients peri-aGVHD onset. Markers of microbial health pre-GVHD onset are associated with longer survival and lower risk of GVHD-related mortality after allo-HCT.

在胃肠道急性移植物抗宿主病（GI-aGVHD）患者的急性GVHD发病围期粪便样本中，可检测到微生物群失调（microbial dysbiosis）的特征谱。GVHD发病前的微生物健康标志物，与异基因造血干细胞移植（allo-HCT）后更长的生存期以及更低的GVHD相关死亡风险存在显著关联。